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Research Publications: James Larkin

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List below show my peer-reviewed academic publications and conference abstracts. At the base of the page is a list of awards and prizes.

Peer-reviewed publications

  1. Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI
    Francisco Perez-Balderas, Sander van Kasteren, Alaa Aljabali, Kim Wals, Guillaume Bort, Seung Seo Lee, Filippo De Simone, Nicola Sibson, Sébastien Serres, Manuel Sarmiento Soto, Alexandre Khrapitchev, James Larkin, Claire Bristow, Sandra Campbell, Robin Choudhury, Daniel Anthony, Andrew Jefferson (2016)
    Nature Communications 8 14254. DOI: 10.1038/ncomms14254.

  2. Determination of an optimally sensitive and specific chemical exchange saturation transfer MRI quantification metric in relevant biological phantoms
    Kevin J Ray, James R Larkin, Yee K Tee, Alexandre A Khrapitchev, Gogulan Karunanithy, Michael Barber, Andrew J Baldwin, Michael A Chappell, Nicola R Sibson (2016)
    NMR in Biomedicine 29 11 1624-1633. DOI: 10.1002/nbm.3614.

  3. Early Diagnosis of Brain Metastases Using a Biofluids-Metabolomics Approach in Mice
    James R Larkin, Alex M Dickens, Timothy DW Claridge, Claire Bristow, Kleopatra Andreou, Daniel C Anthony, Nicola R Sibson (2016)
    Theranostics 6 12 2161-2169. DOI: 10.7150/thno.16538.

  4. NMR-Based Metabolomics Separates the Distinct Stages of Disease in a Chronic Relapsing Model of Multiple Sclerosis
    Dickens AM*, Larkin JR*, Davis BG, Griffin JL, Claridge TD, Sibson NR, Anthony DC
    [* Authors contributed equally, cited alphabetically] (2015)
    Journal of Neuroimmune Pharmacology 10 3 435-44. DOI: 10.1007/s11481-015-9622-0.

  5. The longitudinal cerebrospinal fluid metabolomic profile of amyotrophic lateral sclerosis
    Gray E*, Larkin JR *, Claridge TDW, Talbot K, Sibson NR, Turner MR
    [* Authors contributed equally, cited alphabetically]     (2015)
    Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 16 7-8 456-463. DOI: 10.3109/21678421.2015.1053490.

  6. Molecular Magnetic Resonance Imaging of Angiogenesis In Vivo using Polyvalent Cyclic RGD-Iron Oxide Microparticle Conjugates
    Melemenidis S, Jefferson A, Ruparelia N, Akhtar AM, Xie J, Allen D, Hamilton A, Larkin JR, Perez-Balderas F, Smart SC, Muschel RJ, Chen X, Sibson NR, Choudhury RP (2015)
    Theranostics 5 5 515-29. DOI: 10.7150/thno.10319.

  7. ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1
    Wang Y, Bu F, Royer C, Serres S, Larkin JR, Soto MS, Sibson NR, Salter V, Fritzsche F, Turnquist C, Koch S, Zak J, Zhong S, Wu G, Liang A, Olofsen PA, Moch H, Hancock DC, Downward J, Goldin RD, Zhao J, Tong X, Guo Y, Lu X (2014)
    Nature Cell Biology 16 11 1092-104. DOI: 10.1038/ncb3050.

  8. A type 2 biomarker separates relapsing-remitting from secondary progressive multiple sclerosis
    Dickens AM*, Larkin JR*, Griffin JL, Cavey A, Matthews L, Turner MR, Wilcock GK, Davis BG, Claridge TD, Palace J, Anthony DC, Sibson NR
    [* Authors contributed equally, cited alphabetically] (2014)
    Neurology 83 17 1492-9. DOI: 10.1212/WNL.0000000000000905.

  9. Are brain and heart tissue prone to the development of thiamine deficiency?
    Astrid Klooster, James R. Larkin, Janneke Wiersema-Buist, Rijk O.B. Gans, Paul J. Thornalley, Gerjan Navis, Harry van Goor, Henri G.D. Leuvenink and Stephan J.L. Bakker (2013)
    Alcohol 47 3 215-221. DOI: 10.1016/j.alcohol.2012.12.014.

  10. Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes
    James R. Larkin, Fang Zhang, Lisa Godfrey, Guerman Molostvov, Daniel Zehnder, Naila Rabbani and Paul J. Thornalley (2012)
    PLOS ONE 7 12 e53175. DOI: 10.1371/journal.pone.0053175.

  11. Recent advances in SALDI-MS techniques and their chemical and bioanalytical applications
    Law KP, Larkin JR (2011)
    Analytical and Bioanalytical Chemistry 399 8 2597-2622. DOI: 10.1007/s00216-010-4063-3.

  12. Thiamine in diabetic nephropathy: a novel treatment modality? Reply to Alkhalaf A, Kleefstra N, Groenier KH et al. [letter]
    Rabbani N, Alam SS, Riaz S, Larkin JR, Akhtar MW, Shafi T, Thornalley PJ. (2009)
    Diabetologia 52 6 1214-1216. DOI: 10.1007/s00125-009-1334-7.

  13. Severe thiamine deficiency complicated by weight loss protects against renal ischaemia-reperfusion injury in rats
    Astrid Klooster, James R. Larkin, Antonysunil Adaikalakoteswari, Rijk O. B. Gans, Harry van Goor, Paul J. Thornalley, Naila Rabbani, Gerjan Navis, Henri G. D. Leuvenink and Stephan J. L. Bakker (2009)
    NDT Plus 2 2 182-183. DOI: 10.1093/ndtplus/sfn194.

  14. High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study.
    Rabbani N, Alam SS, Riaz S, Larkin JR, Akhtar MW, Shafi T, Thornalley PJ. (2009)
    Diabetologia 52 2 208-12. DOI: 10.1007/s00125-008-1224-4.

  15. High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease
    Thornalley PJ, Babaei-Jadidi R, Al Ali H, Rabbani N, Antonysunil A, Larkin J, Ahmed A, Rayman G, Bodmer CW (2007)
    Diabetologia 50 10 2164-70. DOI: 10.1007/s00125-007-0771-4.

  16. Accurate and reliable high-throughput detection of copy number variation in the human genome
    Fiegler H, Redon R, Andrews D, Scott C, Andrews R, Carder C, Clark R, Dovey O, Ellis P, Feuk L, French L, Hunt P, Kalaitzopoulos D, Larkin J, Montgomery L, Perry GH, Plumb BW, Porter K, Rigby RE, Rigler D, Valsesia A, Langford C, Humphray SJ, Scherer SW, Lee C, Hurles ME, Carter NP (2006)
    Genome Research 16 12 1566-74. DOI: 10.1101/gr.5630906.

Conference abstracts

  1. Application of multiphase pseudo-continuous ASL for quantitative blood flow measurement in pre-clinical brain metastasis
    Manon A Simard, James R Larkin, Kevin J Ray, Michael A Chappell, Nicola R Sibson
    Poster at 22nd BC ISMRM annual meeting, Leeds, UK (2016)


  2. Multiphase pCASL for imaging blood flow in rodent brains
    James R Larkin, Manon A Simard, Alexandre A Khrapitchev, Kevin J Ray, James A Meakin, Peter Jezzard, Michael A Chappell, Nicola R Sibson
    Talk at 22nd BC ISMRM annual meeting, Leeds, UK (2016)


  3. Assessment of radiation damaged mouse lungs using perfluorohexane liquid MRI
    Alexandre A. Khrapitchev, James R. Larkin, Stavros Melemenidis, Peter Thelwall, Nicola R. Sibson
    Poster at Bio-Imaging conference, Physiological Society, Warwick, UK (2016)


  4. Early Diagnosis of Brain Metastases Through Biofluid Metabolomics
    James R Larkin, Alex M Dickens, Timothy D W Claridge, Daniel C Anthony, Nicola R Sibson
    Talk at BNOS Annual Meeting 2016, Leeds, UK (2016)


  5. Arterial spin labelling MRI of cerebral tumours in rats
    Manon A Simard, James R Larkin, Kevin J Ray, Alexandre A Khrapitchev, James A Meakin, Peter Jezzard, Michael A Chappell and Nicola R Sibson
    Talk at BNOS Annual Meeting 2016, Leeds, UK (2016)


  6. Novel multi-faceted brain metastasis therapy
    Manuel Sarmiento Soto, James R. Larkin, Kleopatra Andreou, Ana Dominguez Bajo, Christina Simoglou Karali and Nicola R. Sibson
    Talk at 4th International Conference on Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging and Therapeutic Targets (Aegean Conferences), Rhodes, Greece (2016)


  7. Assessment of radiation damaged mouse lungs using perfluorohexane liquid MRI
    Alexandre A. Khrapitchev, James R. Larkin, Stavros Melemenidis, Peter Thelwall, Nicola R. Sibson
    E-poster at 24th ISMRM annual meeting, Singapore (2016)


  8. NMR metabolomics of biofluids for early diagnosis of brain metastasis
    James R Larkin, Alex M Dickens, Timothy D W Claridge, Daniel C Anthony, and Nicola R Sibson
    Talk at 24th ISMRM annual meeting, Singapore (2016)


  9. Multiphase pCASL for imaging blood flow in rodent brains
    James R Larkin, Manon A Simard, Alexandre A Khrapitchev, Kevin J Ray, James A Meakin, Paul Kinchesh, Sean Smart, Peter Jezzard, Michael A Chappell, Nicola R Sibson
    Poster at 24th ISMRM annual meeting, Singapore (2016)


  10. Characterizing the Infiltration of Circulating Monocytes Into Brain Metastases
    Vasiliki Economopoulos, Manuel Sarmiento Soto, James R Larkin, Nicola R Sibson
    Poster at AACR annual meeting 2016, New Orleans, USA (2016)


  11. Sensitivity of CEST MRI for pH measurement in brain metastases
    K.J. Ray, J.R. Larkin, Y.K. Tee, A.A. Khrapitchev, M.C. Chappell, N.R. Sibson
    Poster at 21st BC ISMRM annual meeting, London, UK (2015)


  12. Early diagnosis of brain tumours through biofluid metabolomics
    James R Larkin, Alex M Dickens, Timothy D W Claridge, Daniel C Anthony, Nicola R Sibson
    Poster at The XXVIIth International Symposium on Cerebral Blood Flow, Metabolism and Function (Brain), Vancouver, Canada (2015)


  13. Mechanistic pathways underlying altered neurovascular coupling in brain metastasis
    Manuel Sarmiento Soto*, Sébastien Serres*, Claire Bristow, Vasiliki Economopoulos, James R. Larkin, Carole Escartin, Gilles Bonvento and Nicola R. Sibson
    Poster at The XXVIIth International Symposium on Cerebral Blood Flow, Metabolism and Function (Brain), Vancouver, Canada (2015)


  14. Astrocyte activation by brain metastases alters neurovascular coupling
    Sébastien Serres, Manuel Sarmiento Soto, James R. Larkin, James A. Meakin, Alexandr Khrapitchev, Carole Escartin, Gilles Bonvento and Nicola R. Sibson
    Talk at The XXVIIth International Symposium on Cerebral Blood Flow, Metabolism and Function (Brain), Vancouver, Canada (2015)


  15. Sensitivity of CEST MRI for Absolute pH Measurement in Brain Metastases
    Kevin Ray, James Larkin, Yee Kai Tee, Alexandr Khrapitchev, Michael Chappell, Nicola Sibson
    Poster at 23rd ISMRM annual meeting, Toronto, Canada (2015)


  16. Perfluorohexane Liquid MRI of Mouse Lungs in a Dual-Tuned 1H/19F Coil
    Alexandr A. Khrapitchev, James R. Larkin, Stavros Melemenidis, Konstantinos Papoutsis, Peter Thelwall, Nicola R. Sibson
    Poster at 23rd ISMRM annual meeting, Toronto, Canada (2015)


  17. Molecular MRI for the detection of tumour angiogenesis
    Stavros Melemenidis, Danny Allen, Alastair Hamilton, James R Larkin, Francisco Perez-Balderas, Sean C Smart, Ruth Muschel, Xiaoyuan Chen, Robin P Choudhury, Nicola R Sibson
    Poster at 3rd International Conference on Tumour Microenvironment and Cellular Stress, Mykonos, Greece (2014)


  18. Reliable differentiation of multiple sclerosis sub-types by serum NMR metabolomic analysis
    James R Larkin, Alex M Dickens, Daniel C Anthony, Julian L Griffin, Ana Cavey, Lucy Matthews, Benjamin G Davis, Timothy D W Claridge, Jacqueline Palace and Nicola R Sibson
    E-poster at 22nd ISMRM annual meeting, Milan, Italy (2014)


  19. Proton NMR Spectroscopy metabolomics in serum and CSF
    Gray E*, Larkin JR*, Claridge TDW, Talbot K, Sibson NR, Turner MR
    Talk at 24th International Symposium on ALS / MND, Milan, Italy (2013)


  20. Early diagnosis of brain metastases using NMR metabolomics
    James R Larkin, Alex M Dickens, Timothy D W Claridge, Alastair Hamilton, Emma O’Brien, Daniel C Anthony and Nicola R Sibson
    Poster at 3rd Annual Brain Metastases Research and Emerging Therapy Conference, Marseille, France (2013)


  21. Proton Spectroscopy Metabolomics in serum and CSF from the BioMOx ALS cohort
    Gray E*, Larkin JR*, Claridge TDW, Talbot K, Sibson NR, Turner MR
    Poster at ENCALS meeting 2013, Sheffield, UK (2013)


  22. Serum metabolomic analysis reliably differentiates between multiple sclerosis sub-types
    Nicola R. Sibson, James R. Larkin*, Alex M. Dickens*, Julian L. Griffin, Ana Cavey, Lucy Matthews, Benjamin G. Davis, Timothy D.W. Claridge, Jacqueline Palace, Daniel C. Anthony
    Poster at Brain (XXVIth International Symposium on Cerebral Blood Flow, Metabolism and Function), Shanghai, China (2013)


  23. Reliable differentiation of multiple sclerosis sub-types by serum metabolomic analysis
    James R. Larkin, Alex M. Dickens, Daniel C. Anthony, Julian L. Griffin, Ana Cavey, Lucy Matthews, Benjamin G. Davis, Timothy D.W. Claridge, Jacqueline Palace and Nicola R. Sibson
    Poster at British Neuroscience Association Festival of Neuroscience, London, UK (2013)


  24. Pharmacokinetics of thiamine in streptozotocin-induced diabetic rats reveals thiamine mishandling in the kidney, retina and peripheral nerve exposing these tissues to increased risk of thiamine deficiency
    F Zhang, ND Evans, JR Larkin, L Godfrey, N Yamada-Fowler, MJ Chappell, N Rabbani and PJ Thornalley
    Poster at Diabetes UK Annual Professional Meeting, Manchester, UK (2013)
    Diabetic Medicine

  25. A multimodal in vivo MRI study of an intracerebral model of brain metastasis in the rat
    Sébastien Serres, Christopher J. Martin, Manuel Sarmiento Soto, Claire Bristow, James Larkin, Alexander Khrapitchev and Nicola R. Sibson
    Poster at Aegean conference: Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging and Therapeutic Targets, Crete, Greece (2012)


  26. A metabolomics approach for the early diagnosis of brain metastasis
    Alex M. Dickens, Timothy D. W. Claridge, James R. Larkin, Alastair Hamiliton, Emma O'Brien, Daniel C. Anthony, Nicola R. Sibson
    Poster at NCRI Cancer Conference, Liverpool, UK (2011)


  27. Astrocyte activation in response to brain metastasis
    Emma O'Brien, Sébastien Serres, James Larkin, Claire Bristow, Daniel Anthony, Nicola Sibson
    Poster at NCRI Cancer Conference, Liverpool, UK (2011)


  28. Endothelial activation in brain metastasis
    Manuel Sarmiento Soto, Sébastien Serres, Alex M. Dickens, James R. Larkin, Daniel C. Anthony, Nicola R. Sibson
    Poster at NCRI Cancer Conference, Liverpool, UK (2011)


  29. Circulating markers of protein glycation, oxidation and nitration in type 2 diabetes and effect of decline in renal function
    George Jerums, Sianna Panagiotopoulos,Richard J. MacIsaac,Dennis K. Yue, Greg R. Fulcher, Matthew Roberts, James R Larkin, Antonysunil Adaikalakoteswari, Naila Rabbani and Paul J. Thornalley
    Poster at American Diabetes Association 71st Scientific Sessions, San Diego, California, USA (2011)
    Diabetes 60 Supp 1 A166. DOI: 10.2337/db11-478-715

  30. Down Regulation of Thiamine Transporter Expression in Human Tubular Epithelial Cells In Vitro and Increased Thiamine Clearance in Diabetes
    James R Larkin, Naila Rabbani, Daniel Zehnder and Paul J Thornalley
    Talk at American Diabetes Association 71st Scientific Sessions, San Diego, California, USA (2011)
    Diabetes 60 Supp 1 A1. DOI: 10.2337/db11-1-378

  31. Down regulation of thiamine transporter expression in human tubular epithelial cells by high glucose concentration in vitro and increased thiamine clearance in diabetes
    James R Larkin, Naila Rabbani, Daniel Zehnder and Paul J Thornalley
    Poster at British Renal Society Conference, Birmingham, UK (2011)


  32. Intensive insulin therapy attenuates renal thiamine mishandling in streptozotocin-induced diabetic rats
    Fang Zhang, James Larkin, Lisa Godfrey, Naila Rabbani and Paul J Thornalley
    Poster at Diabetes UK Annual Professional Meeting, London, UK (2011)
    Diabetic Medicine 28 Supp s1 63. DOI: 10.1111/j.1464-5491.2011.03233_1.x

  33. High glucose causes a decrease in expression of thiamine transporters in human proximal tubule epithelial cells in vitro
    Larkin JR, Thornalley PJ
    Talk at EASD Annual Meeting, Rome, Italy (2008)
    Diabetologia 51 Supp 1 S97. DOI: 10.1007/s00125-008-1117-6

Awards and prizes

  1. Cancer Research UK Lay poster competition: Runner up (October 2014)
    Awarded based on presentation of a scientific poster designed to covey a scientific project on brain metastasis diagnosis to a lay audience.

  2. Oxford MS Young Investigator 2013 (March 2013)
    Awarded based on a poster presentation and assessed by a small panel including lay people. The poster was marked on scientific merit as well as being able to translate the message to the attending audience.

  3. Post graduate poster fair, Warwick University - Medicine faculty winner and regional finalist (May 2009)
    The emerging role of thiamine in diabetic complications
    James Larkin, Daniel Zehnder, Naila Rabbani and Paul J. Thornalley

  4. Post graduate poster fair, Warwick University - Medicine faculty winner and regional finalist (May 2008)
    Vitamin B1, diabetes and vascular damage – what's the connection?
    Thornalley PJ, Babaei-Jadidi R, Al Ali H, Rabbani N, Antonysunil A, Larkin J, Ahmed A, Rayman G, Bodmer CW

Other presentations

  1. Invited talk at Metastatic Disease Meeting, Oxford, UK. September 2014.

  2. Oxford MS Research Update Day
    Invited talk at Oxford MS Research Update Day, Oxford, UK. March 2013.

  3. Invited talk at IAS symposium for young researchers. December 2008.

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